Recent Publications

Dr. Pavel Klein

  1. Herzog AG, Klein P, Ransil BJ. Three patterns of catamenial epilepsy. Epilepsia 1997;38:1082-1088.
  2. Herzog AG, Klein P, Jacobs AR. Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism. Neurology 1998; 50:782-784.
  3. Klein P, Pezzullo JC, Serje A. Premature ovarian failure in women with epilepsy. Epilepsia 2001;42:1584-1590.
  4. Klein P, van Passell-Clark L, Pezzullo JC. Onset of Epilepsy at the time of menarche. Neurology 2003;60:495-7.
  5. Herzog AG, Coleman AE, Jacobs AR, Klein P, Friedman MN, Drislane FW, Schomer DL. Relationship of sexual function to the laterality and reproductive hormone levels in women with temporolimbic epilepsy. Epilepsy Behav 2003;4:407-13.
  6. Herzog AG, Coleman AE, Jacobs AR, Klein P, Friedman MN, Drislane FW, Ransil BJ, Schomer DL. Interictal EEG discharges, reproductive hormones and menstrual disorders in epilepsy. Ann Neurol 2003;54:625-37.
  7. Sahoo S, Klein P. Maternal Complex partial seizure associated with fetal distress. Arch Neurol 2005;62:1304-05.
  8. Klein P, Sahoo S. Effect of ACTH-induced hypercortisolemia on EEG in patients with stress-related epilepsy. Epilepsy Behav 2005;6:187-190.
  9. Klein P, van Passell-Clark L. Effect of stress related to the 9/11/2001 terror attack on seizures in patients with epilepsy.Neurology 2005;64:1815-16.
  10. Thorneycroft I, Klein P, Simon J. Impact of antiepileptic drug therapy on steroidal contraceptive efficacy. Epilepsy Behav 2006; 9:31-39.
  11. Klein P, Cantero J, Tirol F, Pezzullo JC. Effect of hormonal contraception on seizures in women with epilepsy. Epi Res(submitted).
  12. Klein P, Janousek J, Barber A, Weissberger R. Ketogenic diet treatment in adults with refractory epilepsy. Epilepsy Behav 2010; 19:575-9.
  13. Klein P, Herr D, Pearl PL, Results of Phase II Safety and Feasibility Study of Treatment With Levetiracetam for Prevention of Posttraumatic Epilepsy. Arch Neurol 2012; Jul 9:1-6. doi: 10.1001/archneurol.2012.445.
  14. Klein P, Herr D, Pearl PL, Results of Phase II Pharmacokinetic Study of Levetiracetam for Prevention of Posttraumatic Epilepsy. Epi Behav 2012; 2012 Jul 7.
  15. Pearl PL, Herr D, Klein P. Results of phase II levetiracetam trial following acute head injury in children at risk for post-traumatic epilepsy. Epilepsia 2013; 54: (9):e135-7. doi: 10.1111/epi.12326. Epub 2013 Jul 22.
  16. Klein P, Mathews GC. Antiepileptic drugs and neurocognitive development, Editorial. Neurology 2014; 82:194-195.
  17. Klein P, Tyrlikova I, Mathews GC. Dietary treatment of refractory epilepsy in Adults. Neurology 2014; 83:in press.
  18. Tomson T, Klein P Fine-tuning risk assessment with antiepileptic drug use in pregnancy. Editorial. Neurology 2014; 83: 2015, in press.
  19. Klein P, Tyrlikova I, Mathews G. Dietary treatment in adults with refractory epilepsy, a review. Neurology 2014;83:1978–1985
  20. Klein P, Mathews G. Antiepileptic drugs and neurocognitive development, an editorial. Neurology  2014;82:194–195
  21. Lee D, Kalu U, Halford J, Biton V, Cloyd J, Klein P, Bekersky I, Peng G, Dheerendra S, Tolbert D. Intravenous carbamazepine as short-term replacement therapy for oral carbamazepine in adults with epilepsy: Pooled tolerability results from two open-label trials. Epilepsia 2015, 56(6):906–914
  22. Klein P, Schiemann J, Sperling M, A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures. Epilepsia 2015, 56(12):1890–1898
  23. Ben-Menachem E, Mameniskiene R, Quarato P, Klein P, Gamage J, Schiemann J, Johnson M, Whitesides J, McDonough B, Eckhardt K. Efficacy and safety of brivaracetam for partial-onset seizures in 3 pooled clinical studies. Neurology 2016;87:314–323
  24. Klein P, Tyrlikova I. Prevention of epilepsy: Should we be avoiding clinical trials?. Epilepsy & Behavior 2017; 72:188-194
  25. Klein P, Diaz A, Gasalla T, Whitesides J. A review of the pharmacology and clinical efficacy of brivaracetam. Clinical Pharmacology: Advances and Applications 2018; 10:1-22
  26. Sperling M, Klein P, Tsai J. Randomized, double-blind, placebo-controlled phase 2 study of ganaxolone as add-on therapy in adults with uncontrolled partial-onset seizures. Epilepsia 2017, 58(4):558-564
  27. Benbadis S, Klein P, Schiemann J, Diaz A, Elmoufti S, Whitesides J. Efficacy, safety, and tolerability of brivaracetam with concomitant lamotrigine or concomitant topiramate in pooled Phase III randomized, double-blind trials: A post-hoc analysis. Epilepsy & Behavior 2018; 80: 129-134
  28. Klein P, Dingledine R, Aronica E, et al. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia 2017;00:1-30